Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model
نویسندگان
چکیده
Extracellular pH (pHe) of tumor cells is characteristic microenvironment (TME). Acidic TME impairs the responses tumors to some anti-cancer chemotherapies. In this study, we showed that daily oral dosing sodium potassium citrate (K/Na citrate) increased blood HCO3− concentrations, corresponding increase concentrations and pHs in urine, neutralized pHe. Neutralization acidic by alkaline substance like HCO3−, an active metabolite K/Na citrate, well potentiated therapeutic effect anticancer agent TS-1®, orally 5-fuluoro-uracil derivative, Panc-1 pancreatic cancer-xenograft murine model. using a smart approach for enhancement effects agents cancer end stage.
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ژورنال
عنوان ژورنال: Biological & Pharmaceutical Bulletin
سال: 2021
ISSN: ['1347-5215', '0918-6158']
DOI: https://doi.org/10.1248/bpb.b20-00825